In a recent program that aired on the History Channel, one that was full of sensational errors and propaganda, some bozo speculated that the feral pythons in the Florida Everglades might mate with cobras (which MIGHT also have escaped in the area), creating a new giant super-snake. I'd like to address this right now: it isn't possible. Pythons and cobras are genetically incompatible. Ask any biologist who knows anything about reptiles, and they'll tell you that that's about as likely as a human and a squirrel hybridizing. You can certainly mix python species with one another (and even then, not all are compatible) and the same with cobras and related species, but pythons and cobras...it's not going to happen.
If you don't believe me, then riddle me this: pythons and cobras both come from Africa and Asia and can be found in the exact same geographical locations, yet, in millions of years they have never hybridized. So, sorry, Monster Quest, but the super-snake you're hoping to find is hanging out with the other creatures from your show—El Chupucabra, the Loch Ness monster, Big Foot, Mothman, Champy and the like—in your imagination.